New virus from shithole China

[Bobby]

Death toll nears 300,000

see here:
https://coronaboard.com/

We have done well in Australia with only 98 deaths.

It looks like we all might just make it thanks to
the early strict quarantine.

We must be smarter than the Yanks.
They have over 85,000 deaths
increasing by nearly 2,00 per day.

[Redneck]

Death toll nears 300,000

see here:
https://coronaboard.com/

We have done well in Australia with only 98 deaths.

It looks like we all might just make it thanks to
the early strict quarantine.

We must be smarter than the Yanks.
They have over 85,000 deaths
increasing by nearly 2,00 per day.

Thats not hard with dill brain Donald running the show!!

[Bobby]

Thats not hard with dill brain Donald running the show!!

Are you saying that ScoMo is a better leader than Trump?

[Redneck]

Thats not hard with dill brain Donald running the show!!

Are you saying that ScoMo is a better leader than Trump?

Choke! Choke! Choke!

Mmmmm slightly!

[Bobby]

Thats not hard with dill brain Donald running the show!!

Are you saying that ScoMo is a better leader than Trump?

Choke! Choke! Choke!

Mmmmm slightly!

Trump was too busy playing golf to react fast enough.

He said it would be all over by Easter April 12th.

[Bobby]

I can't edit my post - it should have read:

We must be smarter than the Yanks.
They have over 85,000 deaths
increasing by nearly 2,000 per day.

[Black Orchid]

I see the stupid is spreading.

[Bobby]

I see the stupid is spreading.

Hi BO,
would mind changing the edit time to say 30 minutes or one hour?
It annoys me when I make a mistake and can't edit my post.

[Nom De Plume]

I see the stupid is spreading.

Indeed... Hi ho, hi ho, back on topic we must go.....

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

Since furin is highly expressed in lungs, an enveloped virus that infects the respiratory tract may successfully exploit this convertase to activate its surface glycoprotein (Bassi et al., 2017; Mbikay et al., 1997). Before the emergence of the 2019-nCoV, this important feature was not observed in the lineage b of betacoronaviruses. However, it is shared by other CoV (HCoV-OC43, MERS-CoV, MHV-A59) harbouring furin-like cleavage sites in their S-protein (Fig. 2; Table 1), which were shown to be processed by furin experimentally (Le Coupanec et al., 2015; Mille and Whittaker, 2014). Strikingly, the 2019-nCoV S-protein sequence contains 12 additional nucleotides upstream of the single Arg↓ cleavage site 1 (Fig. 1, Fig. 2) leading to a predictively solvent-exposed PRRAR↓SV sequence, which corresponds to a canonical furin-like cleavage site (Braun and Sauter, 2019; Izaguirre, 2019; Seidah and Prat, 2012). This furin-like cleavage site, is supposed to be cleaved during virus egress (Mille and Whittaker, 2014) for S-protein “priming” and may provide a gain-of-function to the 2019-nCoV for efficient spreading in the human population compared to other lineage b betacoronaviruses. This possibly illustrates a convergent evolution pathway between unrelated CoVs. Interestingly, if this site is not processed, the S-protein is expected to be cleaved at site 2 during virus endocytosis, as observed for the SARS-CoV.

Not a lot of studies on convergent evolution pathways of viruses....

[Black Orchid]