Think you might have that arse about.Jovial Monk wrote:I do take Celebrex which is a COX-1 inhibitor, not COX-1 and COX-2
Marine oil is obviously a mix of many different oils naturally occurring in fish. Some of them are actually exquisitely potent NSAIDS several orders of magnitude more potent than aspirin.take nine fish oil tablets as 3 lots of 3 everyday—these are extremely mild anti inflammatories and are supposedly good for heart and other functions too.
The way they work is actually quite interesting. They are the fish equivalent of human inflammatory molecules. In humans the human version of these molecules cause inflammation by binding to a particular receptor on cells. When taken by a human the fish oil out competes the human inflammatory molecules for the same receptor, but don't cause the inflammation (because they're from a different species, they don't work in humans).
But they make up such a small fraction of the oil that the dose you receive when you take them is very small and thus you don't see much of an effect.
In theory you could increase the anti-inflammatory fraction of the oil by beating the fish up a bit, causing it to synthesise its fishy inflammatory molecules, before harvesting the oil. I wonder if anyone else has thought of this. /patent
Not unless we start funnelling some of the enormous hip-disability and prescription COX-2 inhibitor welfare dollars in our budget (see AM's thread) into medical research, statim.By the time the arthritis in my left hip and lower back is a problem hopefully stem cells to rebuild the joint cartilege will be available.